Therefore, understanding the molecular mechanisms of tubulin activation and deactivation is crucial to designing more effective compounds that overcome cell resistance and lower the toxicity of compounds in clinical use. Due to its central role in cell biology, tubulin is a reference target for antitumor drugs that modulate protein dynamics. MTs perform these functions by serving as scaffolds for other proteins and engaging mechanical forces through their dynamic behavior ( Gigant et al., 2000 Koshland et al., 1988). They are responsible for essential processes during cell growth and division, including chromosome segregation, intracellular transport, cell support and motility ( Desai and Mitchison, 1997). Microtubules (MTs) are ubiquitous cytoskeletal polymers built from α/β-tubulin heterodimers that assemble into a pseudo-helical cylinder. Department of Biological Sciences, Faculty of Science and Engineering, Chuo University, Japan.
University of Basel, Biozentrum, Switzerland.Diffraction and Scattering Division, Japan Synchrotron Radiation Research Institute, Japan.Department of Life Sciences, Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima, Japan.Division of Biology and Chemistry, Laboratory of Biomolecular Research, Paul Scherrer Institut, Switzerland.Departamento de Microbiología y Genética, Universidad de Salamanca-Campus Miguel de Unamuno, Spain.Univ Rennes, CNRS, IGDR (Institut de Génétique et Développement de Rennes) – UMR 6290, France.Structural and Chemical Biology Department, Centro de Investigaciones Biológicas, CSIC, Spain.
0 kommentar(er)
